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It is also important to keep track of your regular visits to ensure that your physician can monitor your response and make any needed adjustments to the dosage. It is widely believed that a drug's effect will increase as the dosage increases, as outlined by the classical pharmacodynamic models. However, this isn't always the case when medications are titrated to effect, which has become known as the "titration paradox." This is due to a variety of factors, including variations in the sensitivity of drugs and the rate that a medication creates its effects. The titration paralyse can also been attributed to the fact that many drugs have multiple pharmacodynamic actions and that it is possible for different subpopulations to require an entirely different dose-response curve to achieve the desired effect. For example the methylphenidate (a popular stimulant medication) could have different release profiles, including certain variants which wear off more quickly than others. 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It allows the drug to reach its maximum efficacy and reduces the risk of adverse reactions. Titration is a key part of determining the proper dosage for stimulant ADHD medication. The goal is to find a dosage that will help to manage the ADHD symptoms, and at the same time minimize any adverse effects present. This can be accomplished by an attentive surveillance of the patient by the doctor, and also by the family. There is a range of individual differences in the amount of a drug that each person requires. This is especially true of stimulants. They can be metabolized in the liver. Different CYP 2D6 genotypes affect the rate of metabolism. Slow metabolizers may require lower doses, whereas rapid metabolizers may need higher dosages. It is important to titrate ADHD medications with care and in a complete manner. During the titration procedure the doctor will examine the patient's reaction to the medication and any adverse events occurring. 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